Product Description: 
PE-22-28 is a synthetic analogue of Spadin, a peptide derived from the propeptide of neurotensin receptor 3 (NTSR3/sortilin). It functions as a selective inhibitor of TREK-1, a two-pore domain potassium channel implicated in depression, anxiety, and neurological function. PE-22-28 has emerged as one of the most promising research compounds in the field of peptide-based antidepressant research.
Current research has explored PE-22-28 in the following contexts: TREK-1 potassium channel inhibition and antidepressant mechanisms, neurogenesis and hippocampal neuron proliferation, serotonin pathway modulation and mood regulation, anxiety and stress response research, and comparative antidepressant mechanism studies versus SSRI pathways.
 
Why Researchers Are Interested in PE-22-28 
PE-22-28 represents a novel mechanism of action in depression research — one that operates independently of traditional serotonin reuptake inhibition. Its ability to promote neurogenesis alongside mood regulation has made it a compelling area of investigation for researchers studying next-generation approaches to neurological health.
 
Specifications: 10mg | Lyophilized powder | Purity ≥98% | Store at 2–8°C
 
For Research Use Only. Not intended for human or veterinary use.